Weight loss research studies

Display only actively recruiting studies. Display all studies. All clinical trial information is pulled directly from ClinicalTrials. This website does not guarantee acceptance into any clinical trial, and is not responsible for adverse events that may be incurred from a clinical trial.

Waiting for a specific trial? Click Here. A division of M3, Inc. Links Home ClinicalTrials. Gastrointestinal Hormonal Regulation of Obesity. Virtual Reality in Inpatients. Healthy Heroes Study. Adaptive Responses to Overfeeding and Weight. Statin Distribution.

Demographics and Findings of Upper Endoscopy Patients. Probiotic Supplementation on Weight Loss. Insulin Regulation of Lipolysis and Lipolysis Proteins. Taste Changes With Bariatric Surgery. Project Take Charge. Pathobiology of Remission of Type 2 Diabetes.

February 27, Most American adults are overweight or obese. Doctors assess weight using body mass index BMI , a ratio of weight to height. A BMI between 25 and Being overweight or obese puts you at risk for a myriad of health problems, such as heart disease, diabetes, and some cancers. Researchers have been studying the influence of diet on weight control.

Some studies have suggested that the proportions of fat, carbohydrate, and protein that people eat may be important for losing weight , although others have not. Doctors sometimes prescribe low-fat or low-carbohydrate diets for weight control. Studies have suggested two potential biological factors for success with different diets: metabolic predisposition and genetic predisposition. A team led by Dr. Christopher D. Gardner of Stanford University explored the influence of certain biological factors on the success of weight loss with low-fat and low-carbohydrate diets.

They analyzed the patterns of genetic variation genotypes in three genes that code for proteins involved in fat and carbohydrate metabolism. The purpose of this study is to determine if employees will use under desk foot pedal elliptical devices at their workstation to increase their level of physical activity.

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Our overall goal is to determine the effect of Phentermine and Topiramate on gastric emptying, gastric accommodation, and satiety and satiation in obese participants. Obesity, defined as a body mass index of Lorcaserin is Leptin is a fat hormone which acts in maintaining energy balance.

However, leptin levels are high in obese subjects indicating resistance to the actions of leptin.

High leptin levels have been associated with increased cardiovascular and metabolic risks, but it is not clear if increased leptin or leptin resistance contributes to the increased cardiovascular risk. Further, even though leptin receptors are present in fat tissue, leptin's role in fat tissue functions are not completely investigated in humans. Based on preliminary data the investigators hypothesize that resistance to leptin action in obese adipose tissue is responsible for altering the expression of This study aims to examine the role of weight gain in adipose tissue immune cell influx and development of obesity related cardiometabolic disorders.

Adipose tissue-mediated chronic systemic inflammation is implicated in the development of cardiometabolic disorders in obesity. Therefore, resolution of adipose tissue inflammation may be key to ameliorating obesity-associated dyslipidemia, insulin-resistance, and cardiovascular disease. Proinflammatory cytokines contribute to the initial influx of immune cells into adipose tissue during weight gain.

However, mechanisms regulating these cytokines in the adipose tissue milieu and the effects of weight gain on adipose tissue are not completely understood. Observational studies suggest that bariatric surgery is the most effective intervention for weight loss. In this study the investigators propose to randomize subjects undergoing SG to receive either placebo or Liraglutide, a The Investigator will conduct the study and analyze the samples at Mayo Clinic in Rochester, Minnesota.

Evidence-Based Complementary and Alternative Medicine

Obesity is common in adults with complex medical problems with ensuing complications afterwards. Obese patients suffer higher mortality and impaired functional status often as a result of their obesity. One primary goal to reduce both obesity and improve functional status is exercise. The investigators hypothesize that a simple exercise intervention with limited behavioral goal-setting will reduce weight and increase functional status compared to usual care.

Interdisciplinary Centers

As a secondary measure, the investigators hypothesize that using this intervention will reduce hospital admissions and ER visits. The purpose of this study is to conduct a social network analysis to identify peer interventionists and to assess existing social structures that contribute to obesity-related health behaviors among Somali and Hispanic immigrants. The hope is this will ultimately help identify biological predictors for matching the best bariatric surgery to the patient for maximizing the effectiveness of the weight loss.

This registry will contain clinical data from individual comprehensive pediatric weight management programs around the United States for overweight and obese youth. Obesity is associated with differences in stomach function, feeling of fullness after meals, and total calories consumed at a buffet meal. Based upon previous research, our study hypothesis is that weight loss with pharmacological agents may be individualized, based on the abnormality in those gastrointestinal functions. Obesity is associated with reduced adenosine triphosphate ATP turnover in skeletal muscle, a condition that can impair muscle metabolism.

The findings will help to develop appropriate interventions to improve The purpose of this study is to define the feasibility and effectiveness of a multi-component intervention aimed at decreasing perception of dyspnea in participants with lung disease who are obese. This study is being done to understand the short and long term changes in gastric emptying in response to the endoscopic sleeve gastroplasty ESG. The primary purpose of this research study is to collect a large enough sample of fat cells preadipocytes and blood from patients undergoing surgery to establish a bank of samples for use by researchers to begin to understand what factors regulate the ability of fat tissue to grow better in some people than others.

The purpose of this study is to find out how the naturally occurring bacteria the microbiome in your gut can affect your body weight. This study is being done to better understand the relationship between inflammation and insulin resistance in your Adipose fat Tissue. With, one in three Americans now having a body mass index BMI greater than 30, and the fastest growing segment of the population having a BMI greater than 40, it is paramount to conduct validation of approaches to measure body composition.

Currently the dual-energy x-ray absorptiometry iDXA is the gold standard for measuring the body composition. But it is often difficult to perform since it is limited to specific height, weight and BMI's. InBody is a tool which uses bio electric impedance to measure the body composition. This study will compare both approaches. Validation is necessary as it is clinically The Researchers are trying to determine if Costoclavicular brachial plexus block CCBPB can be successfully performed in patients with a body mass index greater than thirty.

This research study is being done to evaluate the reliability and reproducibility of an infrared 3D scanner and an iPad app in measuring body measurements in participants. The multi-purpose of this study is to pilot test a social network-informed CBPR-derived health promotion program for feasibility outcomes with overweight or obese adults from two immigrant communities, and to assess the preliminary impact of embedding a social network-informed CBPR-derived intervention within a regional health promotion resource hub on sustainability and uptake outcomes.

The proposed study is a prospective, pilot study to assess the feasibility of a novel endoscopic suturing system to reduce gastric volume by changing the shape of the stomach for the primary treatment of obesity. The investigators aim to recruit ten subjects with a body mass index between for this study. Vertical sutures will be performed using the endoscopic suturing system to deploy interrupted full thickness sutures.