Zoloft weight loss statistics

Weight gain while taking an antidepressant is a conundrum that can leave many people scratching their heads, even doctors. It's entirely possible that the person is simply feeling better and, as a result, eating more.

1. Sertraline.
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In this instance, with antidepressant treatment, further weight gain may indicate failed treatment or it could be medication-induced—a tricky, but extremely critical distinction. To further complicate the picture, while many people associate antidepressant use with weight gain, there is actually limited scientific evidence to back this up.

In addition, individual factors seem to play a role. You may be surprised to learn that there are two antidepressants linked to weight loss. Remember, a link implies a statistical association, so it does not predict individual results. These include:. As an SSRI , Prozac increases the levels of serotonin in the brain and these are generally the first-line treatment for depression. Any weight loss you may experience while taking Prozac may only be temporary and weight gain after the first few months may be possible.

Wellbutrin is an atypical antidepressant that doesn't change serotonin levels in the brain. Rather, it uniquely alters other brain chemicals like noradrenaline and dopamine. This is especially true of people with a history of seizures or an eating disorder like anorexia or bulimia. It could put you at greater risk for having a seizure while using it. This states their potential for increased risk of suicidal thoughts and actions in children, teens, and young adults during the early stages of treatment.

If you are having suicidal thoughts, contact the National Suicide Prevention Lifeline at for support and assistance from a trained counselor. If you or a loved one are in immediate danger, call For more mental health resources, see our National Helpline Database. Treating your depression is paramount to your mental health and well-being.

Of course, your physical appearance and health are also important, and your doctor would not want weight gain to affect your adherence to your depression therapy. Have a candid discussion with your doctor about depression treatment as there are a lot of options out there. If you have concerns about weight loss or gain, talk to your doctor about diet and exercise changes you can make as well.

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Concerns have been raised that suicidal acts among participants in multiple studies were not reported in published articles reporting the studies. Antidepressant discontinuation syndrome is a condition that can occur following the interruption, dose reduction, or discontinuation of antidepressant drugs, including sertraline.

The symptoms can include flu-like symptoms, "brain zaps," and disturbances in sleep, senses, movement, mood, and thinking. In most cases symptoms are mild, short-lived, and resolve without treatment. More severe cases are often successfully treated by temporary reintroduction of the drug with a slower tapering off rate.

WEIGHT GAIN ON LEXAPRO? GOING OFF? ZOLOFT?

Acute overdosage is often manifested by emesis, lethargy, ataxia, tachycardia and seizures. Plasma, serum or blood concentrations of sertraline and norsertraline, its major active metabolite , may be measured to confirm a diagnosis of poisoning in hospitalized patients or to aid in the medicolegal investigation of fatalities. Sertraline had a slight inhibitory effect on the metabolism of diazepam , tolbutamide and warfarin , which are CYP2C9 or CYP2C19 substrates; this effect was not considered to be clinically relevant.

Sertraline had no effect on the actions of digoxin and atenolol , which are not metabolized in the liver. Clinical reports indicate that interaction between sertraline and the MAOIs isocarboxazid and tranylcypromine may cause serotonin syndrome. According to the label, sertraline is contraindicated in individuals taking monoamine oxidase inhibitors or the antipsychotic pimozide Orap. Sertraline concentrate contains alcohol, and is therefore contraindicated with disulfiram Antabuse. Sertraline is a selective serotonin re-uptake inhibitor.

This increases the concentration of serotonin in the synaptic cleft, meaning more is available to act on the post synaptic neurons resulting in antidepressant effects. It is this action that is thought to be responsible for the antidepressant, anxiolytic , and antiobsessional effects of sertraline. Sertraline does not have significant affinity for the norepinephrine transporter NET or the serotonin , dopamine , adrenergic , histamine , or acetylcholine receptors.

Tatsumi et al. Sertraline is associated with a significantly higher incidence of diarrhea than other SSRIs, especially at higher doses. In the blood, it is It appeared unlikely that inhibition of any single isoform could cause clinically significant changes in sertraline pharmacokinetics. These conclusions have not been verified in human studies. Non-amine metabolites may also contribute to the antidepressant effects of this medication. Sertraline deaminated is O , a compound that has been found to inhibit the dopamine reuptake transporter proteins in spite of its lack of a nitrogen atom.

Its chief active metabolite is norsertraline N -desmethylsertraline which is significantly less biologically active than its parent compound.