B12 is a nutrient that supports optimal blood, heart, and brain function, but also plays a vital role in how the body metabolizes fats and carbohydrates.
The specific combination of nutrients gives you added energy and mood enhancement, while helping your body maintain healthy blood sugar levels. While you can get some of these vitamins and nutrients through certain foods or supplements, there is a much higher efficiency rating with injections.
Lipo (MIC) Injection
By injecting B12 and Lipotropic agents, the nutrients bypass the gastrointestinal tract and get straight to work in the cells that need them. Lipotropic compounds can improve overall liver and gallbladder function, protect joints, and help preserve lean muscle. They have also been shown to lower high cholesterol levels and reduce the risk of heart disease. B12 has many health benefits including improved immune system function, enhanced memory, and healthy neurological activity support.
Our bodies also depend on B12 to help reduce stress and continue to grow and repair healthy cells. We offer unique packages and injection options for our weight loss clients. Transformyou: S. Telemedicine Appointments Available. Store Specials Patient Login. Excess circulating glucose is often deposited as fat in the liver and around visceral organs. Dietary supplementation with inositol reduced weight gain and lipid accumulation in the liver of rats.
In its unmodified form, or after oxidation to betaine, choline reduces fat deposition and accelerates the lipid transport. Like methionine, betaine can also methylate DNA and influence gene expression. In addition, choline inhibited obesity-induced oxidative stress and prevented hepatic accumulation of triglycerides. In female athletes, choline supplementation significantly reduced body fat as well as levels of the hunger hormone leptin.
Thus, the dual advantage of consuming fewer calories while burning fats as an energy source may contribute to the lipotropic actions of choline. Methionine is primarily metabolized in the liver. It is transported into hepatocytes via facilitative transport. SAM donates its methyl group, generating S-adenosyl homocysteine, which is then hydrolyzed to adenosine and homocysteine.
Homocysteine may be remethylated to regenerate methionine. Alternatively, it can be converted to cysteine via the transsulfuration pathway. In the salvage pathway, SAM is decarboxylated and used as an aminopropyl donor for polyamine biosynthesis. Decrease in urinary excretion occurred when the subjects were on a high-fat diet. Myo-inositol and inositol phosphate derivatives are primarily absorbed in the gut.
Cellular uptake of inositol occurs via sodium ion-coupled transporters as well as sodium-glucose co-transporters. Because they compete for the same transporters for uptake into cells, high glucose levels can significantly inhibit the uptake of inositol. Renal cortical tubules express the enzyme myo-inositol oxygenase. This enzyme metabolizes myo-inositol via the glucuronate-xylulose pathway, converting it into the monosaccharides xylulose and ribulose.
Inositol that is unmetabolized or not re-absorbed at the renal tubular level is excreted unchanged through urine. Choline obtained through the diet is absorbed by choline transporters in the intestine. Choline is primarily metabolized in the liver. It may also be converted to betaine in a two-step irreversible reaction.
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Betaine contributes methyl groups to the one-carbon pathway, resulting in the regeneration of methionine from homocysteine. The metabolism of choline may be impaired by single nucleotide polymorphisms in genes encoding folate metabolizing enzymes. Furthermore, dietary choline is converted to trimethylamine by gut bacteria. Trimethylamine is oxidized to trimethylamine-N-oxide by flavin monooxygenase 3 FMO3 in the liver.
Trimethylamine-N-oxide is then excreted through urine. There are no randomized, controlled trials studying the effect of Lipo-MIC injections on pregnant and lactating women or their offspring. Human and animal studies on each constituent compound may offer some insights. Excess methionine in the maternal diet may be detrimental to fetal development. This is because additional glycine and serine may be required to catabolize the excess methionine, inadvertently resulting in the deficiency of these amino acids.
Lipo (MIC) Injection (Methionine Inositol Choline) | Empower Pharmacy
Excess methionine may also be metabolized to homocysteine. Elevated plasma homocysteine levels are associated with preeclampsia, spontaneous abortion, placental rupture, and miscarriage. Given its use in the treatment of polycystic ovarian syndrome and gestational diabetes, myo-inositol may be considered relatively safe during pregnancy. In a meta-analysis of randomized controlled trials, 2 g of myo-inositol administered orally twice daily was reported to be safe during pregnancy. Effects of other inositol isomers are not well characterized. Choline requirements are especially high in pregnant women and nursing mothers.
Additionally, consuming more than 3. Women who are pregnant, planning to be pregnant, or are breastfeeding must consult their physician regarding the use of lipotropic injections for weight loss. The methionine metabolite S-adenosyl methionine SAM may interact with antidepressants, antipsychotics, amphetamines, and narcotics causing excess accumulation of serotonin in the body. It may also interact with the cough suppressant dextromethorphan and the dietary supplement St.
Choline and inositol are not known to have any clinically relevant interactions with drugs, supplements, or foods.
Do They Work?
This is not a comprehensive list of adverse effects. If you experience rash, hives, itchiness, shortness of breath, or other symptoms of an allergic reaction, please discontinue use immediately and consult your physician. Side effects may vary from person to person. Upcoming evidence indicates that the choline metabolite trimethylamine-N-oxide may be a risk factor for cardiovascular diseases.
Studies in animal models suggest that TMAO may be atherogenic and prothrombotic. Therefore, Lipo-MIC injections are contraindicated in individuals with cardiovascular disorders. S-adenosyl methionine may worsen the symptoms of mania in people with bipolar disorder. Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain. Lipo MIC Injection. Methionine: Methionine is a sulfur-containing branched-chain amino acid. Choline: Choline is an essential nutrient required for optimal functioning of various tissues including the liver, muscles, and brain.
Mechanisms of Action Methionine: An essential sulfur-containing amino acid, methionine undergoes transmethylation reactions to generate metabolic by-products including S-adenosyl methionine SAM and homocysteine. Choline: In its unmodified form, or after oxidation to betaine, choline reduces fat deposition and accelerates the lipid transport. Pharmacokinetics Methionine is primarily metabolized in the liver.
Interactions The methionine metabolite S-adenosyl methionine SAM may interact with antidepressants, antipsychotics, amphetamines, and narcotics causing excess accumulation of serotonin in the body. Do not flush unused medications or pour down a sink or drain 1. Best, C. Kenney, J. The effect of choline and myo-inositol on liver and carcass fat levels in aerobically trained rats.
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The relative response of hepatic lipids in the rat to graded levels of dietary myo-inositol and other lipotropes. The role of methionine on metabolism, oxidative stress, and diseases. Amino Acids vol. Zhou, X. Methionine restriction on lipid metabolism and its possible mechanisms. Chiang, P. Obeid, R. Homocysteine and lipids: S-Adenosyl methionine as a key intermediate. FEBS Letters vol. Sharma, A. S-adenosylmethionine SAMe for neuropsychiatric disorders: A clinician-oriented review of research.
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