Antiulcer activity was observed against induced gastric mucosal injury in rats when they were pretreated with G. The activity may be associated with the iron in G. Avoid use during pregnancy and lactation due to a lack of clinical and scientific information.
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One study in rats documented decreased maternal body weight gain during gestation. Monitor therapy. Iron: G. Montelukast or leukotriene receptor antagonists : One case report documented fatal liver failure in a patient taking montelukast and 2 dietary supplements, one of which included G. Potassium and calcium supplements: Some commercial G. Serotonin: A mouse study using a commercial polyherbal product containing G.
Caution is advised for patients being treated for pain or taking medications for any psychiatric condition.
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Statins: A case report of rhabdomyolysis was documented in a patient taking a combination herbal medicine containing G. Warfarin: In one case report, the international normalized ratio of a patient returned to normal after he stopped taking a combination herbal product containing G. Fifteen clinical studies involving approximately patients documented very mild adverse reactions, with the most common including headache, dizziness, dry mouth, and GI complaints such as nausea and diarrhea.
In , the FDA announced a voluntary recall of all Hydroxycut dietary supplements for weight loss and warned consumers that the products may cause potentially fatal hepatotoxicity.
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The recall involved 14 multi-ingredient products with different formulations. Prior to the recall, the primary ingredients of Hydroxycut products included G. Criteria from the Drug-Induced Liver Injury Network study were applied to 17 cases of hepatotoxicity linked to Hydroxycut, most with hepatocellular damage, including 9 of the cases reported to the FDA.
Severity was moderate in 11 cases, was severe in 2 cases, required liver transplant in 4 cases, and was fatal in 1 case. Her condition deteriorated and approximately 50 days after initial symptom onset, she underwent successful liver transplantation. Other serious adverse effects associated with Hydroxycut products that were reported to the FDA included seizures, rhabdomyolysis, and cardiovascular disorders.
A near-fatal case of acute necrotizing eosinophilic myocarditis was believed to be associated with G. Despite early complications, including acute kidney injury and sustained ventricular tachycardia that required cardiopulmonary resuscitation, she survived and stabilized quickly within 24 hours of high-dose corticosteroid therapy. Some animal studies document testicular toxicity with G.
A study in obesity-prone mice evaluated long-term supplementation of a high-fat diet with G. The study suggests that long-term ingestion of G. No unusual electrocardiographic effects QTc interval or other electrocardiograph variables were seen over 5 hours in patients taking half the recommended dose of a multicomponent weight loss supplement containing G. This information relates to an herbal, vitamin, mineral or other dietary supplement.
This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs.
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This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product.
This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements.
This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure.
With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Skip to Content. Garcinia Medically reviewed by Drugs. Common Name s : Malabar tamarind Clinical Overview Use The medical literature primarily documents weight loss and lipid-lowering activity for G. Dosing The dosages of G.
Contraindications Avoid use if there is a known allergy or hypersensitivity to any components of G. Interactions The herb has documented drug interactions.
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The fruit hasn't been adequately studied in pregnant women or women who breastfeed. And Garcinia cambogia may be a problem for patients with Alzheimer's or other forms of dementia, Ulbricht said. In , the FDA issued a safety warning after receiving more than 20 reports of severe reactions, including liver damage, in people taking the supplement Hydroxycut. At the time, Hydroxycut contained Garcinia cambogia extract and other compounds, including chromium polynicotinate and Gymnema sylvestre extract.
Lunsford, et al. The subject had taken the supplement for several months before his liver had failed. The researchers report that this is the first known case of acute liver failure known to be tied to Garcinia cambogia.