Weight regain after weight loss is a substantial challenge in obesity therapeutics.
Dieting leads to significant adaptations in the homeostatic system that controls body weight, which promotes overeating and the relapse to obesity. In this review, we focus specifically on the adaptations in white adipose tissues that contribute to the biological drive to regain weight after weight loss. Weight loss leads to a reduction in size of adipocytes and this decline in size alters their metabolic and inflammatory characteristics in a manner that facilitates the clearance and storage of ingested energy.
We present the hypothesis whereby the long-term signals reflecting stored energy and short-term signals reflecting nutrient availability are derived from the cellularity characteristics of adipose tissues. Brown fat contains many more mitochondria than does white fat. These mitochondria are the "engines" in brown fat that burn calories to produce heat. Brown fat has generated interest among researchers because it appears to be able to use regular body fat as fuel. In addition, exercise may stimulate hormones that activate brown fat.
It's too soon to know whether brown fat's calorie-burning properties can be harnessed for weight loss.
Exercise Training Effects on Inflammatory Gene Expression in White Adipose Tissue of Young Mice
In the meantime, be sure to include physical activity in your weight management plans. Donald Hensrud, M.
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When you lose weight, your fat cells don't just let go of fat
See more conditions. Request Appointment. Healthy Lifestyle Weight loss. Products and services. Free E-newsletter Subscribe to Housecall Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Sign up now. What is brown fat? How is it different from other body fat?
Obesity Can Actually Scar Your Fat Tissue, Making Weight Loss Even Harder
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Show references Loh RKC, et al. Human brown adipose tissue as a target for obesity management; beyond cold-induced thermogenesis. Obesity Reviews. Accessed Oct.